Article
Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011
Baerenwaldt Anne, Lux Anja, Danzer Heike, Spriewald Bernd M, Ullrich Evelyn, Heidkamp Gordon, Dudziak Diana, Nimmerjahn Falk
Abstract excerpt
Maintenance of immunological tolerance is crucial to prevent development of autoimmune disease. The production of autoantibodies is a hallmark of many autoimmune diseases and studies in mouse model systems suggest that inhibitory signaling molecules may be important checkpoints of humoral tolerance. By generating humanized mice with normal and functionally impaired Fcγ receptor IIB (FcγRIIB) variants, we show...
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