Article
Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation.
Blood - 1 May 2014
Boilard Eric, Paré Guillaume, Rousseau Matthieu, Cloutier Nathalie, Dubuc Isabelle, Lévesque Tania, Borgeat Pierre, Flamand Louis
Abstract excerpt
Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1 influenza A virus infection, platelets display activation markers. The platelet activation triggers during H1N1 infection remain elusive. We observed that H1N1 induces surface receptor activation, lipid mediator synthesis, and release of microparticles from platelets. These activation processes require the presence of...
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