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Article

Deciphering signatures of mutational processes operative in human cancer.

Cell reports - 31 Jan 2013

Alexandrov Ludmil B, Nik-Zainal Serena, Wedge David C, Campbell Peter J, Stratton Michael R

Abstract excerpt

The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes are poorly characterized. Global sequencing initiatives are yielding catalogs of somatic mutations from thousands of cancers, thus providing the unique...

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Identifiers

PMID: 23318258
DOI: 10.1016/j.celrep.2012.12.008
PMCID: PMC3588146

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