Article

THE SPLICING FACTOR PTBP1 REPRESSES <i>TP63 γ</i> ISOFORM PRODUCTION IN SQUAMOUS CELL CARCINOMA

2021-10-01

Abstract excerpt

<h4>ABSTRACT</h4> The TP63 gene encodes the transcription factor p63. It is frequently amplified or overexpressed in squamous cell carcinomas. Owing to alternative splicing, p63 has multiple isoforms called α, β, γ and δ. The regulatory functions of p63 may be isoform-specific. The α isoform inhibits the epithelial to mesenchymal transition (EMT) and controls apoptosis, while the γ isoform promotes EMT. Here, we...

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Literature Corpus work: 532f2cc2-dc3a-5951-9ac3-a0de6adee632
DOI: 10.1101/2021.10.01.462767

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