Article

ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage Response

2022-06-13

Abstract excerpt

<h4>Background: </h4> The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing variant, is constitutively expressed in the stem cell-containing basal layer of stratified epithelial tissues, including the mammary gland, where it pl...

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Literature Corpus work: cbaf7598-9f46-51ea-aa5d-dfcc3187d09d
DOI: 10.21203/rs.3.rs-1731932/v1

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