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Article

A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria

31 May 2012

Abstract excerpt

Tuberculosis remains one of the most deadly infectious diseases worldwide and is a leading public health problem. Although isoniazid (INH) is a key drug for the treatment of tuberculosis, tolerance to INH necessitates prolonged treatment, which is a concern for effective tuberculosis chemotherapy. INH is a prodrug that is activated by the mycobacterial enzyme, KatG. Here, we show that mycobacterial DNA-binding...

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PMID: 22648414
DOI: 10.1074/jbc.m111.333385

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