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Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis

26 Sept 2013

Abstract excerpt

The emergence and spread of multidrug-resistant strains of Mycobacterium tuberculosis remains a major concern of tuberculosis control programmes worldwide, as treatment depends on low-efficacy, toxic compounds that often lead to poor outcomes. M. tuberculosis develops drug resistance exclusively through chromosomal mutations, in particular single-nucleotide polymorphisms. Moreover, in laboratory assays the...

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PMID: 24072169
DOI: 10.1093/jac/dkt364

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