Article

Sialoglycans Modulate Siglec-5 – TLR4 Interactions in Osteoarthritis

2025-03-19

Abstract excerpt

<h4>Summary</h4> Osteoarthritis (OA) is characterized by chronic, low-grade inflammation that contributes to cartilage degradation and joint pain. We previously identified Siglec-5/14 in synovial fluid of OA patients (OA SF), which prompted us to investigate its interaction with the sialylated proinflammatory receptor TLR4 in monocytes. Here, we reveal an inverse correlation between Siglec-5 and TLR4, suggesting...

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Literature Corpus work: 52f33beb-2698-5996-8902-e6f533af57af
DOI: 10.1101/2025.03.18.643878

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