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Article

Semaphorin4B is elevated in rheumatoid arthritis and enhances the inflammatory phenotype of macrophages and fibroblast-like synoviocytes.

Arthritis research & therapy - 1 Jul 2025

Martínez-Ramos Sara, Rafael-Vidal Carlos, Marty Jaime, Malvar-Fernández Beatriz, Mouriño Coral, Pérez Nair, Altabás Irene, Pan Francisco J Maceiras, Fernández-Fernández David, Conde Carmen, Hanlon Megan M, Smith Conor M, Tak Paul Peter, Veale Douglas J, Fearon Ursula, Pego-Reigosa Jose María, García Samuel

Abstract excerpt

BACKGROUND: Several members of the class 4 semaphorins are involved in the pathogenesis of rheumatoid arthritis (RA), regulating proinflammatory functions, but the role of (Sema)phorin4B remains unexplored. Therefore, the aim of this study was to determine the expression and function of Sema4B in RA. METHODS: Peripheral blood monocytes from healthy controls (HC) and patients with RA were differentiated into M1...

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Identifiers

PMID: 40598553
DOI: 10.1186/s13075-025-03592-x
PMCID: PMC12219977

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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