IL-1beta and TNF-alpha alter the glycophenotype of primary human chondrocytes in vitro.

doi:10.1016/j.carres.2010.02.017

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Article

IL-1beta and TNF-alpha alter the glycophenotype of primary human chondrocytes in vitro.

Carbohydrate research - 2 Jul 2010

Pabst Martin, Wu Shengqian Q, Grass Josephine, Kolb Alexander, Chiari Catharina, Viernstein Helmut, Unger Frank M, Altmann Friedrich, Toegel Stefan

Abstract excerpt

Despite the significance of glycoproteins for extracellular matrix assembly in cartilage tissue, little is known about the regulation of the chondrocyte glycophenotype under inflammatory conditions. The present study aimed to assess the effect of IL-1beta and TNF-alpha on specific features of the glycophenotype of primary human chondrocytes in vitro. Using LC-MS, we found that both cytokines increased overall...

Topics

Chondrocytes
Gene Expression Regulation, Enzymologic
Humans
Interleukin-1beta
Oligosaccharides
Phenotype
Polysaccharides
Sialyltransferases
Tumor Necrosis Factor-alpha

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PMID: 20303074
DOI: 10.1016/j.carres.2010.02.017

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