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Article

Siglecs as modulators of macrophage phenotype and function.

Seminars in immunology - 1 May 2024

Kukan Emily N, Fabiano Gabrielle L, Cobb Brian A

Abstract excerpt

The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors expressed widely on cells of the hematopoietic system. Siglecs recognize terminal sialic acid residues on glycans and often initiate intracellular signaling upon ligation. Cells can express several Siglec family members concurrently with each showing differential specificities for sialic acid linkages to the underlying glycan...

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PMID: 39357273
DOI: 10.1016/j.smim.2024.101887

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