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Article

Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3.

Cellular and molecular life sciences : CMLS - 1 Nov 2018

Weinmann Daniela, Kenn Michael, Schmidt Sebastian, Schmidt Katy, Walzer Sonja M, Kubista Bernd, Windhager Reinhard, Schreiner Wolfgang, Toegel Stefan, Gabius Hans-Joachim

Abstract excerpt

The reading of glycan-encoded signals by tissue lectins is considered a major route of the flow of biological information in many (patho)physiological processes. The arising challenge for current research is to proceed from work on a distinct protein to family-wide testing of lectin function. Having previously identified homodimeric galectin-1 and chimera-type galectin-3 as molecular switches in osteoarthritis...

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Identifiers

PMID: 29934665
DOI: 10.1007/s00018-018-2856-2
PMCID: PMC6182346

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