Article

Benchmarking tissue- and cell type-of-origin deconvolution in cell-free transcriptomics

2026-03-09

Abstract excerpt

Plasma cell-free RNA (cfRNA) reflects tissue- and cell-type-specific activity across pathological states and is a promising biomarker for organ injury and disease. Computational deconvolution methods are widely used to infer organ and cell-type contributions to cfRNA profiles. However, most were originally developed for single-tissue bulk transcriptomes and their performance in body-wide cfRNA settings, where any...

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Literature Corpus work: 52c8513a-c102-544c-9c45-7f27ef5be891
DOI: 10.64898/2026.03.05.709833

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