Cell-type deconvolution for bulk RNA-seq data using single-cell reference: a comparative analysis and recommendation guideline

Abstract excerpt

The accurate estimation of cell type proportions in tissues is crucial for various downstream analyses. With the increasing availability of single-cell sequencing data, numerous deconvolution methods that use single-cell RNA sequencing data as a reference have been developed. However, a unified understanding of how these deconvolution approaches perform in practical applications is still lacking. To address this,...

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