Article

Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex

2024-02-12

Abstract excerpt

<h4>Background</h4> Cellular deconvolution of bulk RNA-sequencing (RNA-seq) data using single cell or nuclei RNA-seq (sc/snRNA-seq) reference data is an important strategy for estimating cell type composition in heterogeneous tissues, such as human brain. Computational methods for deconvolution have been developed and benchmarked against simulated data, pseudobulked sc/snRNA-seq data, or immunohistochemistry refe...

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Literature Corpus work: 129110a4-75a1-5e3a-8df5-6dd1a7b7c5ec
DOI: 10.1101/2024.02.09.579665

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