Article

Integrated whole-genome and transcriptome sequencing reveals divergent evolutionary processes across biliary tract cancer subtypes

2025-12-12

Abstract excerpt

Biliary tract cancer (BTC) comprises a family of rare malignancies subclassified by anatomy and pathology. However, this scheme may obscure shared biology and limit patient stratification. We therefore performed whole-genome and transcriptome sequencing of 169 tumors enriched for tumor cells by laser capture microdissection to identify shared programs in BTC. Network integration across transcriptomic classes ident...

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Literature Corpus work: 52c49def-9f82-533a-a208-a5f5b146b610
DOI: 10.64898/2025.12.12.693962

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