Article

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

2023-01-17

Abstract excerpt

Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-binding domain (RBD) hot spots 1 . Their impact on viral infection, transmission, and efficacy of vaccines and therapeutics remains poorly understood. Here, we demonstrate that recently emerged BQ.1.1. and XBB.1 variants bind ACE2 with high affinity and promote membrane fusion more efficiently than earlier Omicron variants. Struct...

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Literature Corpus work: 529ada7d-38aa-51ba-8ff9-ff13a8801d98
DOI: 10.1101/2023.01.17.523798

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