Article
Neutralization, effector function and immune imprinting of Omicron variants.
Nature - 1 Sept 2023
Addetia Amin, Piccoli Luca, Case James Brett, Park Young-Jun, Beltramello Martina, Guarino Barbara, Dang Ha, de Melo Guilherme Dias, Pinto Dora, Sprouse Kaitlin, Scheaffer Suzanne M, Bassi Jessica, Silacci-Fregni Chiara, Muoio Francesco, Dini Marco, Vincenzetti Lucia, Acosta Rima, Johnson Daisy, Subramanian Sambhavi, Saliba Christian, Giurdanella Martina, Lombardo Gloria, Leoni Giada, Culap Katja, McAlister Carley, Rajesh Anushka, Dellota Exequiel, Zhou Jiayi, Farhat Nisar, Bohan Dana, Noack Julia, Chen Alex, Lempp Florian A, Quispe Joel, Kergoat Lauriane, Larrous Florence, Cameroni Elisabetta, Whitener Bradley, Giannini Olivier, Cippà Pietro, Ceschi Alessandro, Ferrari Paolo, Franzetti-Pellanda Alessandra, Biggiogero Maira, Garzoni Christian, Zappi Stephanie, Bernasconi Luca, Kim Min Jeong, Rosen Laura E, Schnell Gretja, Czudnochowski Nadine, Benigni Fabio, Franko Nicholas, Logue Jennifer K, Yoshiyama Courtney, Stewart Cameron, Chu Helen, Bourhy Hervé, Schmid Michael A, Purcell Lisa A, Snell Gyorgy, Lanzavecchia Antonio, Diamond Michael S, Corti Davide, Veesler David
Abstract excerpt
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood. Here we demonstrate that recently emerged BQ.1.1 and XBB.1.5 variants bind host ACE2 with high affinity and promote membrane...
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