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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees

20 May 2022

Abstract excerpt

Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD has slightly higher ACE2 affinity than BA.1 and slightly reduced neutralization by vaccine serum, possibly associated with its increased transmissibility. Neutralization differences between sub-lineages for mAbs (including therapeutics) mostly arise from...

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PMID: 35662412
DOI: 10.1016/j.cell.2022.05.014

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