Article
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution.
Nature - 1 Feb 2023
Cao Yunlong, Jian Fanchong, Wang Jing, Yu Yuanling, Song Weiliang, Yisimayi Ayijiang, Wang Jing, An Ran, Chen Xiaosu, Zhang Na, Wang Yao, Wang Peng, Zhao Lijuan, Sun Haiyan, Yu Lingling, Yang Sijie, Niu Xiao, Xiao Tianhe, Gu Qingqing, Shao Fei, Hao Xiaohua, Xu Yanli, Jin Ronghua, Shen Zhongyang, Wang Youchun, Xie Xiaoliang Sunney
Abstract excerpt
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of numerous variants that display growth advantages over BA.5 (ref. 1). Despite their divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge on several hotspots. The driving force and destination of such sudden convergent evolution and its effect on humoral immunity remain unclear. Here we demonstrate...
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