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Deciphering the cellular and molecular landscape of cervical cancer progression through single-cell and spatial transcriptomics

28 May 2025

Abstract excerpt

Cervical cancer represents a significant global health challenge, with complex cellular and molecular mechanisms driving its progression from HPV infection to invasive malignancy. This study employed an integrated approach combining single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (stRNA-seq) to comprehensively characterize the tumor microenvironment (TME) across different stages of cervical...

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Cancer Cells and Metastasis
Cancer Genomics and Diagnostics
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40437003
DOI: 10.1038/s41698-025-00948-z

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