Article

Integrated single-cell and spatial analysis identifies context-dependent myeloid-T cell interactions in head and neck cancer immune checkpoint blockade response

2025-03-30

Abstract excerpt

<h4>Background</h4> Approximately 15-20% of head and neck cancer squamous cell carcinoma (HNSCC) patients respond favorably to immune checkpoint blockade (ICB). Previous single-cell RNA-Seq (scRNA-Seq) studies identified immune features, including macrophage subset ratios and T-cell subtypes, in HNSCC ICB response. However, the spatial features of HNSCC-infiltrated immune cells in response to ICB treatment need t...

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Literature Corpus work: 2d14c048-4859-5aee-9c1b-f9ecbba189a0
DOI: 10.1101/2025.03.24.644582

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