Article

Single-cell transcriptome and TCR profiling revealed the immunosuppression caused by Macrophages and T cells in the chemoresistant oral tongue squamous cell carcinoma

2023-07-25

Abstract excerpt

<h4>Background: </h4> After surgical treatment, chemotherapy is one of the most common strategies for advanced oral squamous cell carcinoma (OSCC). The majority of patients, especially those with advanced OSCC of the tongue, are refractory to chemotherapy or have acquired resistance, and the underlying mechanism remains unknown. Methods The transcriptomes of 62,375 single cells from 15 samples (14 primary OTSCC (...

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Literature Corpus work: 8a0108cc-e0ec-551d-b29a-3153eb1e6ddd
DOI: 10.21203/rs.3.rs-3142719/v1

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