TyCHE enables time-resolved lineage tracing of heterogeneously-evolving populations

Abstract excerpt

Phylogenetic methods for cell lineage tracing have driven significant insights into organismal development, immune responses, and tumor evolution. While most methods estimate mutation trees, time-resolved lineage trees are more interpretable and could relate events like cellular migration and differentiation to perturbations like vaccines and drug treatments. However, somatic mutation rates vary dramatically by ce...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Alleles
• Evolution, Molecular
• Genetic Variation
• Models, Genetic
• Mutation
• Mutation Rate
• Phylogeny

Identifiers and source

Literature Corpus work

525fb6d4-f026-5268-9adf-180d7bb75864

DOI

10.1101/2025.10.21.683591