Article

Single cell resolved spatial immune repertoire unveils spatial heterogeneity of lymphoid aggregates in human immune disorders

2025-01-19

Abstract excerpt

Adaptive immunity, mediated by T and B cell responses, is essential for defending against infections and cancers while also being implicated in autoimmune diseases. Tracking T and B cell repertoires in situ at single-cell resolution is essential for understanding adaptive immune responses. To address the lack of tools for in situ single-cell T/BCR (XCR) sequencing, we developed Stereo-XCR-seq, an efficient strat...

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Literature Corpus work: 90f1e0f3-5899-5c5f-8e28-f3efca7b900c
DOI: 10.1101/2025.01.16.630222

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