Article

Stereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis

2021-04-23

Abstract excerpt

Clonally related B cells infiltrate the brain, meninges and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients, but the mechanisms driving the B-cell response and shaping the immunoglobulin repertoires remain unclear. Here, we used single-cell full-length RNA-seq and B-cell receptor reconstruction to simultaneously assess the phenotypes, isotypes, constant region polymorphisms, and the paired heavy- and...

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Literature Corpus work: 5254a917-6d13-5875-8fee-323201f617d1
DOI: 10.1101/2021.04.23.441098

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