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Article

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions

19 Mar 2018

Abstract excerpt

The antigen-specific activation of pathogenic T cells is considered essential in the initiation and maintenance of multiple sclerosis (MS). The site of activation, the differential involvement of CD4+, and CD8+ T cells, their functional phenotype, and specificity, are important aspects to understand MS pathogenesis. The analysis of clonal expansions of brain-infiltrating T cells may reveal local antigen-driven...

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PMID: 29616027
DOI: 10.3389/fimmu.2018.00509

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