Article

Circulating CD138 (syndecan-1) enhances APRIL-mediated autoreactive B cell survival and differentiation in MRL/Lpr mice

2021-05-11

Abstract excerpt

High levels of serum CD138, a heparan sulfate-bearing proteoglycan, correlates with increased disease activity in systemic lupus erythematosus (SLE) patients. Mechanisms responsible for serum CD138 production and its biological function in SLE disease remain poorly understood. In this study, corroborating patient data, we detected an increase in serum CD138 in MRL/Lpr mice parallel to disease activity. Although TC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5230c5ec-e508-54dd-b979-31f3a6b956e9
DOI: 10.1101/2021.05.11.443667

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Circulating CD138 (syndecan-1) enhances APRIL-mediated autoreactive B cell survival and differentiation in MRL/Lpr miceDOI 10.1101/2021.05.11.443667Read

Disease stage-specific pathogenicity of CD138 (syndecan 1)-expressing T cells in systemic lupus erythematosusSemantic proximity Read

CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells.Semantic proximity Read

SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival ProgramsSemantic proximity Read

Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosusSemantic proximity Read

Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 miceSemantic proximity Read

Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.Semantic proximity Read

Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mice.Semantic proximity Read

Soluble CD138 serum levels are not associated with other poor prognostic markers in patients with B-chronic lymphocytic leukaemia.Semantic proximity Read

Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse.Semantic proximity Read

Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.Semantic proximity Read

Formation of different abzymes in autoimmune‐prone MRL‐lpr/lpr mice is associated with changes in colony formation of haematopoietic progenitorsSemantic proximity Read