Article
Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mice.
Journal of neuroimmunology - 1 Oct 2006
Ma Xiaoxing, Foster Jane, Sakic Boris
Abstract excerpt
Autoantibody-mediated compromise of central neurotransmission is a pathogenic mechanism proposed in etiology of neuropsychiatric lupus (NP-SLE). Recent experimental data support the hypothesis that intrathecally-synthesized antibodies play a key role in brain damage and behavioral dysfunction. However, autoantibody-producing plasma cells have not yet been detected in brain tissue. We presently use contemporary...
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