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Article

Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.

Clinical & developmental immunology - 1 Jan 2000

Kikuchi Kentaro, Lian Zhe-Xiong, He Xiao-Song, Ansari Aftab A, Ishibashi Miyuki, Miyakawa Hiroshi, Shultz Leonard D, Ikehara Susumu, Gershwin M Eric

Abstract excerpt

Relatively little is known for the differentiation and maturation process of human B cells to plasma cells. This is particularly important in reconstitution work involving transfer of autoantibodies. To address this issue, we transplanted human peripheral blood mononuclear cells (PBMC) directly into the spleen of irradiated NOD/SCID mice depleted of natural killer cell activity. Within 6 weeks, naive B cells...

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Identifiers

PMID: 14768952
DOI: 10.1080/10446670310001642122
PMCID: PMC2485411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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