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Article

Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.

Cellular & molecular immunology - 1 Feb 2017

You Ming, Dong Guanjun, Li Fanlin, Ma Feiya, Ren Jing, Xu Yujun, Yue Huimin, Tang Ruijing, Ren Deshan, Hou Yayi

Abstract excerpt

A hallmark of systemic lupus erythematosus (SLE) is the consistent production of various auto-antibodies by auto-reactive B cells. Interferon-α (IFN-α) signaling is highly activated in SLE B cells and plays a vital role in the antibody response by B cells. Previous studies have shown that CD180-negative B cells, which are dramatically increased in SLE patients, are responsible for the production of...

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PMID: 26277892
DOI: 10.1038/cmi.2015.61
PMCID: PMC5301152

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BTK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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