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Article

CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells.

JCI insight - 22 Sept 2021

Luo Shunqun, Kwon Juntae, Crossman Assiatu, Park Pyong Woo, Park Jung-Hyun

Abstract excerpt

Invariant NKT (iNKT) cells are potent immunomodulatory cells that acquire effector function during their development in the thymus. IL-17-producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor RORγt. Whether and how CD138 and RORγt contribute to NKT17 cell differentiation, and whether there...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34549726
DOI: 10.1172/jci.insight.148038
PMCID: PMC8492317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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