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Article

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

15 Jul 2023

Abstract excerpt

Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpoint blockade (ICB) in colorectal cancer is needed. Here we report the histone demethylase PHD finger protein 8 (PHF8, KDM7B), a Jumonji C domain-containing protein that erases...

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PMID: 37454216
DOI: 10.1038/s41467-023-39943-y

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