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Article

Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

10 Mar 2021

Abstract excerpt

Early events in an experimental model of mesothelioma development include increased levels of editing in double-stranded RNA (dsRNA). We hypothesised that expression of endogenous retroviruses (ERV) contributes to dsRNA formation and type-I interferon signaling. ERV and interferon stimulated genes (ISGs) expression were significantly higher in tumor compared to non-tumor samples. 12 tumor specific ERV...

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PMID: 33713739
DOI: 10.1016/j.canlet.2021.03.004

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