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Article

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

31 May 2022

Abstract excerpt

The type I interferon response plays a pivotal role in promoting antitumor immune activity in response to radiotherapy. The identification of approaches to boost the radiation-induced type I interferon response could help improve the efficacy of radiotherapy. Here we show that the histone methyltransferase SETDB1 is a potent suppressor of radiation-induced endogenous retrovirus expression. SETDB1 inhibition...

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PMID: 35648422
DOI: 10.1158/0008-5472.can-21-3523

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