Article

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

2023-03-30

Abstract excerpt

Viral mimicry describes the immune response induced by endogenous stimuli such as dsRNA formed by endogenous retroelements. Activation of viral mimicry has the potential to kill cancer cells or augment anti-tumor immune response. Paradoxically, cancer cells frequently present a dysregulated epigenome, leading to increased expression of retroelements. We previously found that ADAR1 p150 upregulation is an adaptatio...

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Literature Corpus work: 3a9926b2-0c18-5a77-905b-5282733afa37
DOI: 10.1101/2023.03.30.531699

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