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Article

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

Cancer cell - 10 Feb 2014

Mudbhary Raksha, Hoshida Yujin, Chernyavskaya Yelena, Jacob Vinitha, Villanueva Augusto, Fiel M Isabel, Chen Xintong, Kojima Kensuke, Thung Swan, Bronson Roderick T, Lachenmayer Anja, Revill Kate, Alsinet Clara, Sachidanandam Ravi, Desai Anal, SenBanerjee Sucharita, Ukomadu Chinweike, Llovet Josep M, Sadler Kirsten C

Abstract excerpt

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of DNA methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, cultured cells, and human tumors to demonstrate that UHRF1 is an oncogene. UHRF1 overexpression in zebrafish hepatocytes destabilizes and delocalizes Dnmt1 and causes DNA hypomethylation and Tp53-mediated senescence. Hepatocellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24486181
DOI: 10.1016/j.ccr.2014.01.003
PMCID: PMC3951208

Genes

UHRF1

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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.PMID 24486181Read ↗

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