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Article

Distinct D-box motifs in SPD-2 mediate APC/CFZR-1-dependent degradation and centrosomal localization in Caenorhabditis elegans embryos.

G3 (Bethesda, Md.) - 3 Jun 2026

Yim Rachel N, DiPanni Joseph R, Rivera Paollette A, Song Mi Hye

Abstract excerpt

Centrosome duplication must be tightly regulated to maintain genomic stability. In Caenorhabditis elegans, the APC/C and co-activator FZR-1 function as negative regulators of centrosome duplication by targeting specific substrates for proteolytic degradation. While C. elegans SAS-5 and ZYG-1 have been identified as substrates of APC/CFZR-1, the mechanism by which APC/CFZR-1-dependent degradation influences...

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Source

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Identifiers

PMID: 41885187
DOI: 10.1093/g3journal/jkag071
PMCID: PMC13232524

Genes

APC
CEP192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Distinct D-box motifs in SPD-2 mediate APC/CFZR-1-dependent degradation and centrosomal localization in Caenorhabditis elegans embryos.PMID 41885187Read ↗

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