Article

Analysis of the human kinome and phosphatome reveals diseased signaling networks induced by overexpression

2018-05-04

Abstract excerpt

Kinase and phosphatase overexpression drives tumorigenesis and drug resistance in many cancer types. Signaling networks reprogrammed by protein overexpression remain largely uncharacterized, hindering discovery of paths to therapeutic intervention. We previously developed a single cell proteomics approach based on mass cytometry that enables quantitative assessment of overexpression effects on the signaling networ...

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Literature Corpus work: 5f0479cb-9c90-55bf-9fff-e4d6ffb0bee2
DOI: 10.1101/314716

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