Article
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
Molecular systems biology - 5 Nov 2013
Li Jiannong, Bennett Keiryn, Stukalov Alexey, Fang Bin, Zhang Guolin, Yoshida Takeshi, Okamoto Isamu, Kim Jae-Young, Song Lanxi, Bai Yun, Qian Xiaoning, Rawal Bhupendra, Schell Michael, Grebien Florian, Winter Georg, Rix Uwe, Eschrich Steven, Colinge Jacques, Koomen John, Superti-Furga Giulio, Haura Eric B
Abstract excerpt
We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein-protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems-level perspective of the molecular etiology. Here, we describe an EGFR interactome of 263 proteins and offer a 14-protein...
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