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Article

Signaling networks assembled by oncogenic EGFR and c-Met

7 Jan 2008

Abstract excerpt

A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutations respond clinically to EGFR inhibitors (EGFRIs), suggests that responsive tumors uniquely depend on EGFR signaling for their survival. The nature of this dependence...

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PMID: 18180459
DOI: 10.1073/pnas.0707270105

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