Article

BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer

2021-07-15

Abstract excerpt

BAZ2A is the repressor of rRNA genes that are transcribed by RNA Polymerase I. In prostate cancer (PCa), however, BAZ2A function goes beyond this role since it can also repress other genes that are frequently silenced in metastatic disease. However, the mechanisms of BAZ2A-mediated repression in PCa remain elusive. Here we show that BAZ2A represses genes implicated in PCa through its RNA-binding TAM domain using m...

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Literature Corpus work: 51d92e5c-6d49-55b5-a766-3098e315996b
DOI: 10.1101/2021.07.15.452487

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