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Increased MYBL2 expression in aggressive hormone‐sensitive prostate cancer

10 Sept 2022

Abstract excerpt

Loss of the histone demethylase KDM5D (lysine-specific demethylase 5D) leads to in vitro resistance of prostate cancer cells to androgen deprivation therapy (ADT) with and without docetaxel. We aimed to define downstream drivers of the KDM5D effect. Using chromatin immunoprecipitation sequencing (ChIP-seq) of the LNCaP cell line (androgen-sensitive human prostate adenocarcinoma) with and without silenced KDM5D,...

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PMID: 36087093
DOI: 10.1002/1878-0261.13314

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