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Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer

6 Dec 2022

Abstract excerpt

Epigenetics is an emerging mechanism for tumorigenesis. Treatment that targets epigenetic regulators is becoming an attractive strategy for cancer therapy. The role of epigenetic therapy in prostate cancer (PCa) remains elusive. Previously we demonstrated that upregulation of histone lysine demethylase KDM4B correlated with the appearance of castration resistant prostate cancer (CRPC) and identified a small...

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PMID: 36495660
DOI: 10.1016/j.biopha.2022.114077

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Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancerPMID 36495660Read ↗

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