Article

Neuronal toxicity and recovery from early bortezomib-induced neuropathy: targeting the blood nerve barrier but not the dorsal root ganglion

2024-06-01

Abstract excerpt

The use of the first in class proteasome inhibitor Bortezomib (BTZ) is highly effective in the treatment of multiple myeloma. However, it’s long-term use is limited by the fact, that most treated patients develop dose limiting painful polyneuropathy. In some of the treated patients, pain resolves after variable timeframes, in others it persists, despite the discontinuation of treatment, with the underlying mechani...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51d32dd4-baea-5bac-ae72-e345f6b803ef
DOI: 10.1101/2024.05.31.596821

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal toxicity and recovery from early bortezomib-induced neuropathy: targeting the blood nerve barrier but not the dorsal root ganglionDOI 10.1101/2024.05.31.596821Read

TrkA abundance is increased in cutaneous nerves in bortezomib-induced neuropathySemantic proximity Read

Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathySemantic proximity Read

Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.Semantic proximity Read

Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone painSemantic proximity Read

Screening for axonal retraction and cytotoxicity using dorsal root ganglia explants to treat pain caused by aberrant nerve sproutingSemantic proximity Read

Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathySemantic proximity Read

Bortezomib-induced peripheral neuropathy: A genome-wide association study on multiple myeloma patients.Semantic proximity Read

Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathiesSemantic proximity Read

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients.Semantic proximity Read

Neuropathy; its profile and experimental nerve injury neuropathic pain models: A ReviewSemantic proximity Read

Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathySemantic proximity Read

Genetic variation associated with bortezomib-induced peripheral neuropathy.Semantic proximity Read