Article
Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone pain
2022-12-30
Abstract excerpt
Multiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain. However, the mechanisms underlying myeloma-induced bone pain (MIBP) are mostly unknown. Using a syngeneic MM mouse model, we show that periosteal nerve sprouting of calcitonin-gene related protein (CGRP + ) and growth associated protein 43 (GAP43 + ) fibres occurs concurrent to the onset of nociception and its blockade provides...
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Identifiers and source
- Literature Corpus work
- 74b85b68-7557-5702-b3f3-43a5f1e684c5
- DOI
- 10.1101/2022.12.29.522199