Article

Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

2022-02-18

Abstract excerpt

Human peripheral neuropathies are poorly-understood, and the availability of experimental models limits further research. The PeriTox test uses immature dorsal root ganglia (DRG)-like neurons, derived from induced pluripotent stem cells (iPSC), to assess cell death and neurite damage. Here, we explored the suitability of matured peripheral neuron cultures for detection of sub-cytotoxic endpoints, such as altered r...

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Literature Corpus work: b5f79532-e347-542c-85aa-f5a521e5c803
DOI: 10.1101/2022.02.17.479688

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