Article

Increased neuronal activity restores circadian function in <i>Drosophila</i> models of C9orf72-ALS/FTD

2025-08-11

Abstract excerpt

<h4>Summary</h4> Circadian rhythm disruptions are common across neurodegenerative diseases, but their link to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. The C9orf72 hexanucleotide repeat expansion is the most prevalent genetic cause of ALS/FTD. Here, we used Drosophila models expressing toxic arginine-rich dipeptides (PR or GR) or GGGGCC hexanucleotide repeats to inve...

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Literature Corpus work: 8287f848-f8a7-5c95-a231-e2f9904bd090
DOI: 10.1101/2025.08.07.669085

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