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Article

Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.

Infection and immunity - 1 Nov 2009

Putze Johannes, Hennequin Claire, Nougayrède Jean-Philippe, Zhang Wenlan, Homburg Stefan, Karch Helge, Bringer Marie-Agnés, Fayolle Corinne, Carniel Elisabeth, Rabsch Wolfgang, Oelschlaeger Tobias A, Oswald Eric, Forestier Christiane, Hacker Jörg, Dobrindt Ulrich

Abstract excerpt

A genomic island encoding the biosynthesis and secretion pathway of putative hybrid nonribosomal peptide-polyketide colibactin has been recently described in Escherichia coli. Colibactin acts as a cyclomodulin and blocks the eukaryotic cell cycle. The origin and prevalence of the colibactin island among enterobacteria are unknown. We therefore screened 1,565 isolates of different genera and species related to the...

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Identifiers

PMID: 19720753
DOI: 10.1128/IAI.00522-09
PMCID: PMC2772509

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Source receipt: pubmed, retrieved 7 Sept 2026.

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