Article

Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

2019-10-16

Abstract excerpt

<h4>Summary</h4> Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3’ end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA. The addition of a poly(A) tail to the H3.1 mRNA caused transformation of human cells in vitro , but the underlying mechanisms are unknown. Here w...

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Literature Corpus work: 517c8026-5185-573d-b1eb-126dcead1c43
DOI: 10.1101/806828

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